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Detoxification and breaking down substances: Methylation is essential in the nervous system, in the production and breakdown of neurotransmitters, and in detoxifying some specific environmental toxicants such as arsenic

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Second, it modulates the NF-B signaling pathway, which is closely associated with inflammation, by inhibiting RNA polymerase II activity, leading to decreased NF-B-mediated gene transcription and a reduction in the expression of pro-inflammatory factors such as VCAM-1, TGF-, C3, and CD40

doi: 10.1016/j.jemermed.2011.06.017

GLP-1RAs downregulate inducible NOS (iNOS) and dual oxidase 1 (DUOX1), both of which contribute to oxidative stress and epithelial damage [65, 116, 126]